Anti-Aging Treatments That Are Actually Evidence-Based
By Charles Kamen, MD, board-certified neurologist
The most important fact about anti-aging treatments is also the least marketable: no treatment reverses aging. The honest, evidence-based goal is healthspan — extending the years you spend healthy, strong, and clear-headed by slowing age-related decline. Within that frame, some interventions are strongly supported by research, some are promising but early, and some are pure marketing.
Dr. Charles Kamen, MD, a board-certified neurologist at LiveNow Longevity in Las Vegas, builds plans around that distinction: proven foundations first, measured with objective biomarkers, with NAD+, peptides, and medical weight management layered on only where the data support them. Individual results vary with any approach.
What Are the Most Evidence-Based Anti-Aging Treatments?
The most evidence-based anti-aging treatments are the least glamorous: regular exercise, protein-adequate nutrition, quality sleep, and management of metabolic risk. These are the foundation of any real longevity medicine plan, and no peptide, drip, or supplement replaces them. Everything layered on top supports the fundamentals — it never substitutes for them:
- Biomarker-guided optimization — lab testing that turns guesswork into a measurable plan.
- NAD+ and cellular energy support — restoring a coenzyme central to mitochondrial function that declines with age.
- Physician-supervised peptides — studied compounds used as monitored adjuncts, not self-directed stacks.
- Medical weight management — improving metabolic health, one of the strongest levers on how you age.
Lifestyle and Metabolic Foundations
Lifestyle and metabolic foundations have the deepest evidence base of any anti-aging category, which is why a longevity plan should begin here. Physical activity — particularly a combination of resistance training and cardiovascular exercise — is one of the most consistently proven interventions for extending healthy years.
Resistance training builds and preserves lean muscle — the body's largest site for glucose disposal — which supports insulin sensitivity. Protein-adequate nutrition maintains that muscle, quality sleep restores metabolic and cognitive function, and keeping fasting insulin and inflammation in range addresses some of the most powerful drivers of accelerated aging.
What the evidence supports: these foundations meaningfully affect how you age. What it does not support: skipping them in favor of a shortcut. Our review of exercise and longevity research covers the data in depth.
Biomarker Testing and Optimization
You cannot optimize what you do not measure. Comprehensive lab testing — metabolic, inflammatory, and hormonal markers — gives a physician the data to identify what is genuinely off track and to confirm whether an intervention is working. This is the engine of evidence-based anti-aging care: test, intervene, re-test, adjust.
What the evidence supports: markers like HbA1c, fasting insulin, and hs-CRP are well-validated indicators of metabolic and inflammatory health. What it does not support: treating every out-of-range value in isolation, or chasing experimental 'biological age' scores as if they were precise. Our guide to key biomarkers explains which markers matter most.
NAD+ and Cellular Energy
NAD+ is a coenzyme central to cellular energy production and mitochondrial function, and its levels decline with age. That decline is well-documented, and NAD+ and its precursors are an active area of longevity research. Some early human studies show precursors can raise NAD+ levels; how much that translates into clinical benefit is still being worked out.
Because the brain and muscle are among the most energy-demanding tissues in the body, age-related mitochondrial decline is one plausible contributor to the low energy and mental fog patients often describe — a link Dr. Kamen weighs from his vantage point as a neurologist.
What the evidence supports: NAD+ levels fall with age, and restoring them is biologically plausible and actively studied. What it does not support: claims that NAD+ reverses aging or guarantees a specific outcome. It is best considered within a supervised plan. Learn more about NAD+ for healthy aging and how it is evaluated before use.
Peptides as Physician-Supervised Options
Several peptides are studied for functions relevant to aging — growth-hormone signaling, tissue repair, and body composition. They are among the most discussed compounds in longevity medicine, but the human evidence for many of them is earlier-stage, and several are not FDA-approved drugs. When appropriate, they are prescribed by a physician and sourced from licensed compounding pharmacies.
What the evidence supports: plausible, actively studied mechanisms and a role as an adjunct within a supervised plan. What it does not support: self-directed stacking based on online claims, or treating peptides as a substitute for the foundations. Peptides are one input — guided by labs, monitored over time, and stopped if they are not helping.
Medical Weight Management
Metabolic health is one of the strongest levers on how you age, which makes medically supervised weight management a legitimate part of an evidence-based plan for patients who need it. FDA-approved GLP-1 medications have robust clinical-trial data for weight loss, and physician supervision keeps the focus on muscle preservation and metabolic markers, not the scale alone.
What the evidence supports: improving metabolic health meaningfully affects healthspan, and approved medications have strong trial data. What it does not support: using these tools without medical evaluation, or treating weight loss as a cosmetic shortcut rather than a metabolic intervention.
Key Takeaways
- No treatment reverses aging — the realistic goal is healthspan, the years you spend healthy and functional, not a younger number.
- Lifestyle and metabolic foundations — exercise, protein, sleep, and metabolic control — have the strongest evidence and come first.
- Biomarker testing turns guesswork into a measurable, adjustable plan, tracked with markers like HbA1c, fasting insulin, and hs-CRP.
- NAD+ and peptides are biologically plausible and actively studied, but human evidence varies and they belong under physician supervision.
- Medical weight management improves metabolic health — a strong lever on healthspan — when supervised with attention to muscle and labs.
- Individual results vary — a credible plan is tracked with objective markers and changed when it is not working.
Common Questions
What anti-aging treatments actually work?
The strongest evidence supports lifestyle and metabolic foundations — exercise, protein-adequate nutrition, sleep, and managing metabolic risk. Biomarker-guided optimization, NAD+, physician-supervised peptides, and medical weight management can add value, but they work best layered on those foundations, not used instead of them.
Can any treatment reverse aging?
No. No treatment reverses aging. Evidence-based anti-aging medicine aims to slow age-related decline and extend healthspan — the years you spend healthy, strong, and mentally sharp. Any clinic promising to turn back the clock has stepped outside what the research actually supports.
Is NAD+ proven to slow aging?
NAD+ levels decline with age, and restoring them is biologically plausible and actively studied. Some early human data show precursors can raise NAD+ levels, but it is not proven to reverse aging, and it is best used within a physician-supervised plan alongside the foundations.
Do I need a physician for anti-aging treatments?
For anything affecting your internal physiology — labs, NAD+, peptides, weight-loss medications — yes. A physician evaluates your data, individualizes the plan, and monitors your response, which is what separates evidence-based care from a product purchase. Dr. Kamen supervises each of these at LiveNow Longevity.
Can medical weight management help me age better?
Yes, for patients who need it. Metabolic health is one of the strongest levers on healthspan, and FDA-approved GLP-1 medications have robust trial data. Under supervision, the goal is losing visceral fat while preserving muscle and improving metabolic markers — a metabolic intervention, not a cosmetic shortcut.
How do I know if an anti-aging plan is actually working?
You measure it. A credible plan sets a baseline with metabolic, inflammatory, and hormonal markers, then re-tests to confirm interventions are moving the numbers in the right direction. If a marker is not improving, the plan changes. Objective tracking is what separates medicine from marketing.
Evidence-based anti-aging medicine is honest by design: it builds on proven foundations, measures what matters, and layers in interventions only where the data support them — to help you feel and function better, not to sell a miracle. See what a measured, physician-led plan looks like with longevity medicine at LiveNow Longevity.
Wondering what’s right for you?
Get a straight answer from board-certified neurologist Dr. Charles Kamen, MD. The evaluation is $88 and is applied toward your protocol if you continue care.